Genomics

Ireland has the highest rates of haemochromatosis in the world. Approximately 1 in 83 are at risk of developing haemochromatosis and 1 in 5 are carriers of the gene. Haemochromatosis is a condition where too much iron builds up in the body, this can lead to some serious health problems as the body can't get rid of the excess iron. Excess iron can build up in various areas of the body: - liver - skin - heart - pancreas - joints - pituitary gland This build-up of iron can lead to tissue and organ damage. Many people with haemochromatosis don't have noticeable symptoms, but when symptoms do appear they vary between individuals. Some common symptoms include: - fatigue and weakness - weight loss - low sex drive - abdominal pain - bronze or grey skin colour - joint pain There are two types of haemochromatosis: 1. Primary Haemochromatosis aka Hereditary Haemochromatosis This results from genetic factors. Usually, someone with this type of haemochromatosis inherits a defective HFE gene from both parents. The HFE gene controls how much iron you absorb from your food. However, not everyone who inherits the genes develops haemochromatosis. 2. Secondary Haemochromatosis This results from another medical issue causing the iron build-up. In this disease, red blood cells often release too much iron as they are too fragile. Risk factors for Secondary Haemochromatosis include: - alcohol dependency - a family history of diabetes, heart disease or liver disease - taking too many iron and vitamin C supplements - frequent blood transfusions Our Iron Status Blood Test covers 5 key iron related markers that can be used to determine haemochromatosis. One that is especially important, is Transferrin Saturation, a useful measure of how much iron is bound to the protein transferrin. THIS IS NOT INCLUDED BUT CAN BE ADDED TO YOUR TEST AT THE SAME TIME. What does the Genetic Haemochromatosis Blood Test cover? Our test involves the detection of the three most common mutations of the HFE gene, these are: - HFE C282Y - HFE H63D - HFE S65C Who should get the Genetic Haemochromatosis Blood Test? It should be carried out to diagnose or rule out haemochromatosis in symptomatic individuals with evidence of iron overload. Book your Genetic Haemochromatosis Blood Test in Dublin or Kildare today. Most results in within 7 working days. PLEASE NOTE: You are not required to fast for this test and we recommend that you come warm and well hydrated. This is a blood draw test.

Coeliac Disease is a condition where your body's immune system attacks your own tissues when you eat gluten. This damages the small intestine, so the body cannot properly absorb nutrients. Gluten is found in three types of cereal: - wheat - barley - rye Foods containing those types of cereal (and therefore gluten) include: - most breads - pasta - cakes - breakfast cereals - beer - certain sauces - certain ready meals Symptoms of Coeliac Disease When eating foods that contain gluten, it can trigger a range of gut issues, such as: - diarrhoea - stomach aches - bloating and flatulence - indigestion - constipation Some more general symptoms of Coeliac Disease include: - fatigue - unintentional weight loss - an itchy rash - infertility What does the Genetic Coeliac Disease Test cover? Our test involves the detection of HLA-DQB1*02, DQB1*03:02, DQA1*05 and DQA1*03 alleles by RT-PCR from extracted genomic DNA. This allows us to determine the HLA-DQ2 and HLA-DQ8 antigens associated with coeliac disease. The HLA-DQ2 is present in around 90% of people with coeliac disease, whilst the HLA-DQ8 is present in 5 - 8% of people with coeliac disease. It's important to note: CARRYING THE GENE DOES NOT MEAN THAT YOU WILL DEFINITELY DEVELOP COELIAC DISEASE, but it might mean that you develop it at some point in your lifetime. A positive result in coeliac gene testing suggests a likelihood of disease, rather than a certainty. Don't wait any longer to find out if you have a Coeliac Disease gene. Book your Coeliac Disease Genetic Test in Dublin or Kildare today. Results within 7 days. PLEASE NOTE: You are not required to fast for this test and we recommend that you come warm and well hydrated. This is a blood draw test.

This comprehensive test analyses 40 key genetic markers to provide personalised insights into your dietary needs, fitness potential and overall wellness. Genes are small sections of our DNA that encode instructions that determine individual characteristics like eye colour, hair colour and other physical characteristics. Genetic testing is used to screen for changes or mutations in genes that can determine whether you are predisposed or at an increased risk of developing certain conditions. Everyone absorbs, metabolises and transports nutrients differently based on their genetic makeup. A healthy lifestyle can influence how our genes express themselves (how they turn on and off) and these changes may reduce disease risk including obesity and Type 2 Diabetes, even if you are genetically predisposed. You'll get a personalised report providing insights on obesity risk, diabetes risk, muscle recovery, predisposition to nutritional deficiencies, injury risk and much more. With this report you can alter your diet, lifestyle and training habits to get the best out of your genetic make up. Genes Tested and Their Insights: 1. Diet and Nutrition: Saturated Fats Response – ACE, APOA2 Lactose Intolerance – MCM6 Gluten Intolerance – HLA-DQ2.5, HLA-DQ8 Sweet Taste Perception – TAS1R3 Bitter Taste Perception – TAS2R38 Fasting Response – GNB3 Vitamin A Deficiency Risk – BCOM1 Vitamin B12 Deficiency Risk – TCN1, MTHFR Folate Deficiency Risk - MTHFR Vitamin C Deficiency Risk – SLC23A1, SLC23A2 Vitamin D Deficiency Risk – GC, CYP2R1 Magnesium Deficiency Risk – TRPM6 Selenium Deficiency Risk – SEP15 Zinc Deficiency Risk – CA1 Calcium Deficiency Risk – LRP5 Omega 3 and Omega 6 Benefit – FADS1, FADS2 2. Athletic Performance: Muscle Mass - MSTN Muscle Composition – ACTN3, AGTR2 Muscle Recovery – IL-6 Injury Risk – COL5A1 Creatine Conversion - CKM 3. Genetic Obesity Risk – FTO, MC4R Genetic Type II Diabetes Risk – SLC30A8, TCF7L2 Hypertension Risk – ADD1 High Cholesterol and Cardiovascular Disease Risk - LDLR Familial Hypercholesterolaemia - APOB Caffeine Metabolism – CYP1A2, ADORA2A Sleep – CLOCK, GABRA6 Mental Health – HTR1B, NPAS2 Your DNA never changes meaning one test will provide personalised health results for life! Remember, carrying a risk variant does not necessarily mean you will develop a disease, you may just be at higher risk of developing the disease. This test is a blood draw. There are no special requirements before testing and results take six weeks.